A year after a supermoon’s light activated a dormant gene, transforming humans into bloodthirsty werewolves and causing nearly a billion deaths, the nightmare resurfaces as the supermoon rises again. Two scientists attempt to stop the mutation but fail, leaving those exposed to the moonlight to once again become feral werewolves. Chaos engulfs the streets as the scientists struggle to reach one of their family homes, now under siege by the savage creatures.

Told in flashbacks, Mufasa is an orphaned cub, lost and alone until he meets a sympathetic lion named Taka—the heir to a royal bloodline. The chance meeting sets in motion a journey of misfits searching for their destiny and working together to evade a threatening and deadly foe.

Kraven Kravinoff's complex relationship with his ruthless gangster father, Nikolai, starts him down a path of vengeance with brutal consequences, motivating him to become not only the greatest hunter in the world, but also one of its most feared.

The past catches up with a vigilante cop who faked his own death in order to raise his daughter in peace.