A woman answers a help wanted ad to be a housekeeper in a mysterious high-rise in New York City, not realizing she is entering a community that has seen a number of disappearances over the years and may be under the grip of a Satanic cult.

Having thwarted Bowser's previous plot to marry Princess Peach, Mario and Luigi now face a fresh threat in Bowser Jr., who is determined to liberate his father from captivity and restore the family legacy. Alongside companions new and old, the brothers travel across the stars to stop the young heir's crusade.

As rival gangs, corrupt officials and a ruthless Major Iqbal close in, Hamza's mission for his country spirals into a bloody personal war where the line between patriot and monster disappears in the streets of Lyari.

Scientists have discovered how to 'hop' human consciousness into lifelike robotic animals, allowing people to communicate with animals as animals. Animal lover Mabel seizes an opportunity to use the technology, uncovering mysteries within the animal world beyond anything she could have imagined.